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Very poor/Considerable Metabolizers, CYP2D6 The development of the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. About 7% on the inhabitants has lessened exercise of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These persons are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic a